Since 1999, CLDP has engaged both governments and the private sector across the length and breadth of Sub-Saharan Africa, assisting countries from Nigeria, Cameroon, Ghana, Senegal, and Mali in West Africa, to Ethiopia, Kenya, Uganda, Rwanda and Tanzania in East Africa, and Angola, Mozambique, Botswana, Malawi, and South Africa in Southern Africa. In addition to various countries, CLDP has engaged the Regional Economic Communities – the Economic Community of West African States (ECOWAS), the East African Community (EAC), the Common Market for Eastern and Southern Africa (COMESA) and the Southern African Development Community (SADC) – in the harmonization of laws and policies designed to facilitate African economic integration. 

Working primarily through USAID funded programs (the African Trade and Investment Program (ATRIP), the African Global Competitiveness Initiative (AGCI), CLDP focused, inter alia, on adopting the legal and regulatory framework and improving capacity to better implement: the protection and utilization of intellectual property (IP) rights, public procurement reform, technology transfer, project finance, adjudication of commercial disputes, alternative dispute resolution mechanisms, and government ethics and transparency. These CLDP programs were designed to foster an improved trade and investment relationship with the U.S.